Combigene får 1,5 miljoner euro i första utbetalning - Finwire

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The disease affects an estimated 0.6 to 0.8 percent of the world’s population. In 2016 there were 5.7 million diagnosed epilepsy patients in the USA, the EU5* and Japan. About one-third of these patients do not respond to conventional medical treatment. CombiGene begins a proof-of-concept study of CG01 in a chronic epilepsy model.

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In 2016 there were 5.7 million diagnosed epilepsy patients in the USA, the EU5* and Japan. About one-third of these patients do not respond to conventional medical treatment. CombiGene gears up in epilepsy project. 3 september, 2020. Today CombiGene announced the signing of a production agreement with the Spanish gene therapy manufacturer Viralgen for the production of the drug candidate CG01. The choice of partner is based on the fact that Viralgen can manufacture the candidate on a large scale, which means both cost CombiGene now focuses on the completion of the preclinical program for the CG01 epilepsy project this year and to be able to begin studies in humans in 2022.

Gene Therapy , CombiGene , plasmid dna , CG01 , epilepsy. The agreement is part of preparations for GMP production of material for the first clinical study of CG01.

CombiGene on the International Epilepsy Day and the

Den 20 mars inledde bolaget en företrädesemission som skall avancera huvudprojektet CG01, vilket är inriktat på fokal epilepsi, på dess väg  som EU ska dela ut till Combigene för fortsatt utveckling och kommersialisering av ett genterapiprojekt med fokus på svårbehandlad epilepsi. Life science-bolaget Combigene har genomfört en framgångsrik CG01 som utvecklats för behandling av läkemedelsresistent fokal epilepsi. AKTIEANALYS.

Combigene epilepsy

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CombiGene gears up in epilepsy project. 3 september, 2020. Today CombiGene announced the signing of a production agreement with the Spanish gene therapy manufacturer Viralgen for the production of the drug candidate CG01. The choice of partner is based on the fact that Viralgen can manufacture the candidate on a large scale, which means both cost CombiGene now focuses on the completion of the preclinical program for the CG01 epilepsy project this year and to be able to begin studies in humans in 2022. An important piece of the puzzle in this plan fell into place last week. British and Swedish authorities confirms CombiGene’s plan up to the first study in humans 2021-04-08 · CombiGene – the leading Nordic gene therapy company CombiGene is currently conducting two gene therapeutic development projects: one for treatment of epilepsy that cannot otherwise be treated with drugs and one for treatment of lipodystrophy, a rare condition characterized by an abnormal distribution of fatty tissue in the body. CombiGene is a Swedish gene therapy company that develops a gene therapeutic treatment for epilepsy.

Combigene epilepsy

Generoath AAV vector Epilepsy – not defined: Preclinical. Redpin Therapeutics AAV vector Epilepsy – not defined: Preclinical. Research group from UCL AAV vector containing Kv1.1 -based potassium channel Focal In 2021, CombiGene's epilepsy project CG01 will focus on the final preclinical studies. In parallel, the company will intensify preparations for studies in humans, known as clinical studies, which are scheduled to begin in 2022.
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Combigene epilepsy

CombiGene is awarded the “Seal of Excellence” by the EU Horizon 2020 framework programme and receives 500,000 kronor from Vinnova. Human expression study confirms that human brain cells can express CombiGene’s candidate drug, CG01. 2018 Cobra Biologics will produce the AAV viral vector for Combigene’s epilepsy gene therapy from its facilities in Keele, UK. Nordic gene therapy company Combigene’s CG01 candidate is based on an adeno-associated viral vector (AAV) which administers a combination of neuropeptide Y (NPY) and its receptor Y2 directly to the part of the brain where epileptic seizures begin. With the third payment from Horizon 2020, the EU program has so far invested EUR 2.85 million out of a total of EUR 3.36 million on CombiGene’s epilepsy project CombiGene one step closer to clinical trials 1 oktober, 2020 In recent weeks, CombiGene has lined up several milestones on the way to the goal of initiating clinical … Cobra Biologics, part of the Cognate BioServices family, an international CDMO manufacturer of biological materials and pharmaceuticals, and CombiGene AB (publ), the leading gene therapy company in the Nordic region, today announced that they have signed agreements covering Good Manufacturing Practice (GMP) production of two essential plasmids needed for the manufacture of CG01, a gene … Cobra Biologics, part of the Cognate BioServices family, an international Contract Development and Manufacturing Organisation (CDMO) for biologics and pharmaceuticals, and CombiGene AB (publ), the leading gene therapy company in the Nordic region, today announced that Cobra has successfully produced and supplied two further DNA plasmids for the production of CombiGene’s gene therapy … On 15 May 2018, CombiGene announced that Horizon 2020 – EU’s Framework Programme for Research and Development – is investing EUR 3.36 million in CombiGene’s continued development and commerzialisation of the gene therapy project CG01, which is developed to treat drug-resistant focal epilepsy..

This development project is in a late preclinical phase with the first human study scheduled for … CombiGene is a Swedish gene therapy company that develops a gene therapeutic treatment for epilepsy. This development project is in a late preclinical phase with the first human study scheduled for … Collaboration supports progression of Epilepsy Gene Therapy toward clinical trials. CombiGene AB (publ), a leading Nordic gene therapy company, today signed an agreement with the Anglo-Swedish Contract Development and Manufacturing Organisation (CDMO) Cobra Biologics for production of candidate drug CG01. The production of CG01 will be of a quality Yesterday, CombiGene announced the signing of a production agreement with the Spanish gene therapy manufacturer Viralgen for the production of the drug candidate CG01. The choice of partner is based on the fact that Viralgen can manufacture the candidate on a large scale, which means both cost savings and faster development of CG01, a gene therapy developed for the treatment of patients with Horizon 2020 continues to invest in CombiGene´s epilepsy project With the third payment from Horizon 2020, the EU program has so far invested EUR 2.85 million out of a total of EUR 3.36 million on Combi CombiGene begins a proof-of-concept study of CG01 in a chronic epilepsy model.
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Aug 17, 2020 “Cobra is excited to continue that journey with CombiGene and their CG01 epilepsy gene therapy drug candidate." Source: Cobra. Related  CombiGene is currently conducting two gene therapeutic development projects: one Engage Therapeutics. Business Area(s):. Epilepsy. Description  3 days ago It focuses on the research of therapy for patients with epilepsy. The company was founded by Lars Thunberg, Merab Kokaia and David Woldbye  CombiGene AB is a gene therapy explorer based in Sweden. new methods for the treatment of neurological diseases and for epileptic patients who cannot be  Jan 17, 2018 The company says initial data from the preclinical proof-of-concept-study, show that CombiGene's CG01 reduces the frequency of epileptic  Sep 15, 2020 development of quality control analytical assays for clinical production of CombiGene's AAV-based gene therapy for the treatment of epilepsy  CombiGene AB engages in the development of new treatment for neurological diseases.

In parallel, the company will intensify preparations for studies in humans, known … Cobra Biologics, part of the Cognate BioServices family and CombiGene announced Cobra has successfully produced and supplied two further DNA plasmids for the production of CombiGene’s gene therapy drug candidate CG01, which is being developed for the treatment of drug-resistant focal epilepsy. BioStock: CombiGene gears up in epilepsy project Fri, Sep 04, 2020 08:55 CET. Yesterday, CombiGene announced the signing of a production agreement with the Spanish gene therapy manufacturer Viralgen for the production of the drug candidate CG01. At the same time, CombiGene has now a production method that is suitable also for scaling up for future commercial production for the treatment of patients with drug-resistant focal epilepsy”, says Jan Nilsson, CEO of CombiGene. “We are very excited about this collaboration.
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Articles about epilepsy and gene therapy - combigene

Genterapibolaget CombiGene som utvecklar en ny behandling mot läkemedelsresistent fokal epilepsi, fokuserar nästa år på de avslutande prekliniska studierna  22 mars 2021 — CombiGene kommer under 2021 att ha ett tydligt fokus på att för genterapiprojektet CG01 mot läkemedelsresistent fokal epilepsi, som  22 mars 2021 — CombiGenes genteraptiprojekt CG01 mot läkemedelsresistent fokal epilepsi har blockbusterpotential. Då projektet under 2022 går in i en  9 feb. 2021 — Yesterday was International Epilepsy Day which aims to put the spotlight on a devastating disease caused by overactive nerve cells in the brain  CombiGene celebrates International Epilepsy Day (MFN). 2021-02-08 09:00. The International Epilepsy Day is held on the second Monday of February each  Ungefär 60 miljoner människor i världen lider av epilepsi och epileptiska anfall. CombiGene har genom att kombinera framsteg inom neurovetenskap och  With the recruitment of Pernilla Fagergren, CombiGene strengthens the company further for the clinical studies in the epilepsy project CG01 - combigene. CombiGene är ett av nordens ledande genterapibolag, där verksamhetens huvudfokus riktas åt att ta fram en genterapeutisk behandlingsmetod för epilepsi.


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BioStock: CombiGene on the International Epilepsy - IPOhub

On 15 May 2018, CombiGene announced that Horizon 2020 – EU’s Framework Programme for Research and Development – is investing EUR 3.36 million in CombiGene’s continued development and commerzialisation of the gene therapy project CG01, which is developed to treat drug-resistant focal epilepsy. CombiGene There are 50 million people in the world living with epilepsy, of which 81,000 lives in Sweden. The purpose of International Epilepsy Day is for all the world’s epilepsy associations to jointly acknowledge and highlight the disease and its consequences. Last week, CombiGene reported that the company’s two warrants were exercised at 98.4 percent, which thus added just over SEK 25 million to the company.